Highly in demand as a painter in his hometown of Palermo and elsewhere, Antonino Grano also made etchings that he intended for use in personal devotions. As the inscription indicates, Saint Peregrine is a first-century Catholic saint venerated on January 30 as the first bishop of the diocese of Triocala in Sicily.

The etching shows the saint vanquishing a dragon that had been terrorizing the Sicilian town of Caltabellotta, accompanied by a small boy he rescued from being fed to the monster.